Interplay between IL-17 family members and angiogenic cytokines in subjects with systemic sclerosis.

Introduction Systemic sclerosis (SSc) is a chronic, autoimmune connective tissue disease characterized by immune system activation, vasculopathy, and collagen accumulation. Despite progressive fibrosis of the vasculature, compensatory angiogenesis impaired. The cause shift towards anti-angiogenesis observed in SSc unknown. IL-17 cytokine family participates pathogenesis angiogenesis. Material methods Our study aimed to evaluate levels find relationships between proangiogenic cytokines from 42 subjects 20 healthy controls. VEGF, PlGF, HGF, TGFβ1, GM-CSF, IL-17A, IL-17B, IL-17E IL-17F were quantified sera all participants ELISA sandwich kits. Results Significantly higher mean concentrations PlGF compared controls - value (19.3 pg/ml group vs. 11.4 control group; p<0.001) HGF (1931 1483 controls; p<0.05). Mean serum TGFβ1 level was also significantly lower (781 pg/ml) than (35991 pg/ml; p<0.001). Among family, IL-17B (67.0 2.6 p<0,001), (8.0 vs 0.64 (0.42 0.0 p< 0.01) detected. Serum correlated with IL17A, IL-17E. Conclusions In conclusion, our findings indicate that selected IL17 participate are responsible for vascular abnormalities associated this disorder.